Dataset Information

Extracellular Degradation Into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD⁺-Produced Increases in the Adenylate Pool of BV2 Microglia Under Basal Conditions.

ABSTRACT: Cumulating evidence has indicated NAD⁺ deficiency as a common central pathological factor of multiple diseases and aging. NAD⁺ supplement is highly protective in various disease and aging models, while two key questions have remained unanswered: (1) Does extracellular NAD⁺ also produce its effects through its degradation product adenosine? (2) Does extracellular NAD⁺ produce the protective effects by affecting cells under pathological insults only, or by affecting both normal cell and the cells under pathological insults? Since extracellular NAD⁺ can be degraded into adenosine, and endogenous adenosine levels are in the nanomolar range under physiological conditions, extracellular NAD⁺ may produce its effects through its deg

SUBMITTER: Zhang J

PROVIDER: S-EPMC6200843 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Dataset Information

Extracellular Degradation Into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD⁺-Produced Increases in the Adenylate Pool of BV2 Microglia Under Basal Conditions.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Extracellular Degradation Into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD+-Produced Increases in the Adenylate Pool of BV2 Microglia Under Basal Conditions.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Extracellular Degradation Into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD⁺-Produced Increases in the Adenylate Pool of BV2 Microglia Under Basal Conditions.