Mutational Evolution of Pseudomonas aeruginosa Resistance to Ribosome-Targeting Antibiotics.

ABSTRACT: The present work examines the evolutionary trajectories of replicate Pseudomonas aeruginosa cultures in presence of the ribosome-targeting antibiotics tobramycin and tigecycline. It is known that large number of mutations across different genes - and therefore a large number of potential pathways - may be involved in resistance to any single antibiotic. Thus, evolution toward resistance might, to a large degree, rely on stochasticity, which might preclude the use of predictive strategies for fighting antibiotic resistance. However, the present results show that P. aeruginosa populations evolving in parallel in the presence of antibiotics (either tobramycin or tigecycline) follow a set of trajectories that present common elements. In addition, the pattern of resistance mutatio

SUBMITTER: Sanz-Garcia F 

PROVIDER: S-EPMC6200844 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature