Salvage reirradiation for local failure of prostate cancer after curative radiation therapy: Association of rectal toxicity with dose distribution and normal-tissue complication probability models.

ABSTRACT:

Purpose

This study aimed to assess the impact of radiation dose on rectal toxicity after salvage external beam radiation therapy (EBRT) with or without a brachytherapy boost for exclusive local failures after the primary EBRT for prostate cancer.

Methods and materials

Fourteen patients with no severe residual late toxicity after primary EBRT ± brachytherapy were reirradiated after a median time interval of 6.1 years. The median normalized total dose in 2 Gy fractions (NTD_2Gy, α/β ratio = 1.5 Gy for prostate cancer cells) was 74 Gy at primary EBRT and 85.1 Gy at reirradiation. Rectal dose-volume histograms (converted to NTD_{2Gy_alpha/beta = 3 Gy}) and the corresponding normal-tissue complication probability (NTCP) values for gastrointestinal (GI) toxicity

SUBMITTER: Dipasquale G 

PROVIDER: S-EPMC6200893 | biostudies-literature | 2018 Oct-Dec

REPOSITORIES: biostudies-literature