Bordetella pertussis Whole Cell Immunization, Unlike Acellular Immunization, Mimics Naive Infection by Driving Hematopoietic Stem and Progenitor Cell Expansion in Mice.

ABSTRACT: Hematopoietic stem and progenitor cell (HSPC) compartments are altered to direct immune responses to infection. Their roles during immunization are not well-described. To elucidate mechanisms for waning immunity following immunization with acellular vaccines (ACVs) against Bordetella pertussis (Bp), we tested the hypothesis that immunization with Bp ACVs and whole cell vaccines (WCVs) differ in directing the HSPC characteristics and immune cell development patterns that ultimately contribute to the types and quantities of cells produced to fight infection. Our data demonstrate that compared to control and ACV-immunized CD-1 mice, immunization with an efficacious WCV drives expansion of hematopoietic multipotent progenitor cells (MPPs), increases circulating white blood

SUBMITTER: Varney ME 

PROVIDER: S-EPMC6200895 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature