Identification of FDA-Approved Drugs as Antivirulence Agents Targeting the <i>pqs</i> Quorum-Sensing System of Pseudomonas aeruginosa.

ABSTRACT: The long-term use of antibiotics has led to the emergence of multidrug-resistant bacteria. A promising strategy to combat bacterial infections aims at hampering their adaptability to the host environment without affecting growth. In this context, the intercellular communication system quorum sensing (QS), which controls virulence factor production and biofilm formation in diverse human pathogens, is considered an ideal target. Here, we describe the identification of new inhibitors of the pqs QS system of the human pathogen Pseudomonas aeruginosa by screening a library of 1,600 U.S. Food and Drug Administration-approved drugs. Phenotypic characterization of ad hoc engineered strains and in silico molecular docking demonstrated that the antifungal drugs clotrimazo

SUBMITTER: D'Angelo F 

PROVIDER: S-EPMC6201120 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature