Argentilactone Molecular Targets in Paracoccidioides brasiliensis Identified by Chemoproteomics.

ABSTRACT: Paracoccidioidomycosis (PCM) is the cause of many deaths from systemic mycoses. The etiological agents of PCM belong to the Paracoccidioides genus, which is restricted to Latin America. The infection is acquired through the inhalation of conidia that primarily lodge in the lungs and may disseminate to other organs and tissues. The treatment for PCM is commonly performed via the administration of antifungals such as amphotericin B, co-trimoxazole, and itraconazole. The antifungal toxicity and side effects, in addition to their long treatment times, have stimulated research for new bioactive compounds. Argentilactone is a compound that was isolated from the Brazilian savanna plant Hyptis ovalifolia, and it has been suggested to be a potent antifungal, inhibiting the dimorphism

SUBMITTER: Silva LDC 

PROVIDER: S-EPMC6201122 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature