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Carbapenem Resistance Caused by High-Level Expression of OXA-663 ?-Lactamase in an OmpK36-Deficient Klebsiella pneumoniae Clinical Isolate.

ABSTRACT: Carbapenem resistance is mainly mediated by carbapenemases or extended-spectrum ?-lactamases (ESBL) plus a loss of porins. However, we have identified a Klebsiella pneumoniae clinical isolate that contains neither carbapenemases nor ESBLs. Instead, we found that high-level expression of a novel bla OXA-10-derived ?-lactamase gene, bla OXA-663, in conjunction with OmpK36 deficiency results in high-level carbapenem resistance. This finding demonstrates the combinatorial complexity of factors, including ?-lactamase activity, its expression levels, and porin activity, that yield carbapenem resistance.

SUBMITTER: Ma P 

PROVIDER: S-EPMC6201135 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Carbapenem Resistance Caused by High-Level Expression of OXA-663 β-Lactamase in an OmpK36-Deficient Klebsiella pneumoniae Clinical Isolate.

Ma Peijun P   Laibinis Hannah H HH   Ernst Christoph M CM   Hung Deborah T DT  

Antimicrobial agents and chemotherapy 20181024 11

Carbapenem resistance is mainly mediated by carbapenemases or extended-spectrum β-lactamases (ESBL) plus a loss of porins. However, we have identified a <i>Klebsiella pneumoniae</i> clinical isolate that contains neither carbapenemases nor ESBLs. Instead, we found that high-level expression of a novel <i>bla</i><sub>OXA-10</sub>-derived β-lactamase gene, <i>bla</i><sub>OXA-663</sub>, in conjunction with OmpK36 deficiency results in high-level carbapenem resistance. This finding demonstrates the  ...[more]

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