Environmental Surveillance Reveals Complex Enterovirus Circulation Patterns in Human Populations.

ABSTRACT:

Background

Enteroviruses are common human pathogens occasionally associated with severe disease, notoriously paralytic poliomyelitis caused by poliovirus. Other enterovirus serotypes such as enterovirus A71 and D68 have been linked to severe neurological syndromes. New enterovirus serotypes continue to emerge, some believed to be derived from nonhuman primates. However, little is known about the circulation patterns of many enterovirus serotypes and, in particular, the detailed enterovirus composition of sewage samples.

Methods

We used a next-generation sequencing approach analyzing reverse transcriptase polymerase chain reaction products synthesized directly from sewage concentrates.

Results

We determined whole-capsid genome sequences of multiple enterovirus strains

SUBMITTER: Majumdar M 

PROVIDER: S-EPMC6201154 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature