Efficacy, effectiveness, and safety of herpes zoster vaccines in adults aged 50 and older: systematic review and network meta-analysis.

ABSTRACT:

Objective

To compare the efficacy, effectiveness, and safety of the herpes zoster live attenuated vaccine with the herpes zoster adjuvant recombinant subunit vaccine or placebo for adults aged 50 and older.

Design

Systematic review with bayesian meta-analysis and network meta-analysis.

Data sources

Medline, Embase, and Cochrane Library (inception to January 2017), grey literature, and reference lists of included studies.

Eligibility criteria for study selection

Experimental, quasi-experimental, and observational studies that compared the live attenuated vaccine with the adjuvant recombinant subunit vaccine, placebo, or no vaccine in adults aged 50 and older. Relevant outcomes were incidence of herpes zoster (primary outcome), herpes zoster ophthalmicus, post-he

SUBMITTER: Tricco AC 

PROVIDER: S-EPMC6201212 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature