Deletion of caveolin-1 attenuates LPS/GalN-induced acute liver injury in mice.

ABSTRACT: Acute hepatic injury caused by inflammatory liver disease is associated with high mortality. This study examined the role of caveolin-1 (Cav-1) in lipopolysaccharide (LPS) and D-galactosamine (GalN)-induced fulminant hepatic injury in wild type and Cav-1-null (Cav-1^-/- ) mice. Hepatic Cav-1 expression was induced post-LPS/GalN treatment in wild-type mice. LPS/GalN-treated Cav-1^-/- mice showed reduced lethality and markedly attenuated liver damage, neutrophil infiltration and hepatocyte apoptosis as compared to wild-type mice. Cav-1 deletion significantly reduced LPS/GalN-induced caspase-3, caspase-8 and caspase-9 activation and pro-inflammatory cytokine and chemokine expression. Additionally, Cav-1^-/- mice showed suppressed expression of Toll-like receptor

SUBMITTER: Tsai TH 

PROVIDER: S-EPMC6201225 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature