LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance.

ABSTRACT: Targeting autophagy in cancer cells and in the tumor microenvironment are current goals of cancer therapy. However, components of canonical autophagy play roles in other biological processes, adding complexity to this goal. One such alternative function of autophagy proteins is LC3-associated phagocytosis (LAP), which functions in phagosome maturation and subsequent signaling events. Here, we show that impairment of LAP in the myeloid compartment, rather than canonical autophagy, induces control of tumor growth by tumor-associated macrophages (TAM) upon phagocytosis of dying tumor cells. Single-cell RNA sequencing (RNA-seq) analysis revealed that defects in LAP induce pro-inflammatory gene expression and trigger STING-mediated type I interferon responses in TAM. We found that the anti-tumo

SUBMITTER: Cunha LD 

PROVIDER: S-EPMC6201245 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature