Discordant Alternans as a Mechanism for Initiation of Ventricular Fibrillation In Vitro.

ABSTRACT: Background Ventricular tachyarrhythmias are often preceded by short sequences of premature ventricular complexes. In a previous study, a restitution-based computational model predicted which sequences of stimulated premature complexes were most likely to induce ventricular fibrillation in canines in vivo. However, the underlying mechanism, based on discordant-alternans dynamics, could not be verified in that study. The current study seeks to elucidate the mechanism by determining whether the spatiotemporal evolution of action potentials and initiation of ventricular fibrillation in in vitro experiments are consistent with model predictions. Methods and Results Optical mapping voltage signals from canine right-ventricular tissue (n=9) were obtained simultaneously from the entire epicardium

SUBMITTER: Munoz LM 

PROVIDER: S-EPMC6201417 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature