Plasma Cystathionine and Risk of Incident Stroke in Patients With Suspected Stable Angina Pectoris.

ABSTRACT: Background Cystathionine is an intermediate product in the transsulfuration pathway and formed during the B6-dependent conversion of methionine to cysteine. Elevated plasma cystathionine has been related to atherosclerosis, which is a major etiological factor for ischemic stroke. However, the role of cystathionine in stroke development is unknown. Therefore, we prospectively assessed the association of circulating levels of cystathionine with risk of total and ischemic stroke. Methods and Results Two-thousand thirty-six patients (64% men; median age, 62 years) undergoing coronary angiography for suspected stable angina pectoris were included. Stroke cases were identified by linkage to the CVDNOR (Cardiovascular Disease in Norway) project. Hazard ratios with confidence intervals (95% confid

SUBMITTER: Dhar I 

PROVIDER: S-EPMC6201441 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature