Attenuation of diet-induced hypothalamic inflammation following bariatric surgery in female mice.

ABSTRACT:

Background

Exposure of rodents to chronic high-fat diet (HFD) results in upregulation of inflammatory markers and proliferation of microglia within the mediobasal hypothalamus. Such hypothalamic inflammation is associated with metabolic dysfunction, central leptin resistance, and maintenance of obesity. Bariatric surgeries result in long-term stable weight loss and improved metabolic function. However, the effects of such surgical procedures on HFD-induced hypothalamic inflammation are unknown. We sought to characterize the effects of two bariatric surgical procedures, Roux-en-Y gastric bypass (RYGB) and biliary diversion (BD-IL), in female mice with particular emphasis on HFD-induced hypothalamic inflammation and microgliosis.

Methods

RYGB and BD-IL were performed on diet-i

SUBMITTER: Herrick MK 

PROVIDER: S-EPMC6201532 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature