Adult height and risk of 50 diseases: a combined epidemiological and genetic analysis.

ABSTRACT:

Background

Adult height is associated with risk of several diseases, but the breadth of such associations and whether these associations are primary or due to confounding are unclear. We examined the association of adult height with 50 diseases spanning multiple body systems using both epidemiological and genetic approaches, the latter to identify un-confounded associations and possible underlying mechanisms.

Methods

We examined the associations for adult height (using logistic regression adjusted for potential confounders) and genetically determined height (using a two-sample Mendelian randomisation approach with height-associated genetic variants as instrumental variables) in 417,434 individuals of white ethnic background participating in the UK Biobank. We undertook pathw

SUBMITTER: Lai FY 

PROVIDER: S-EPMC6201543 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature