Sex differences in hepatic one-carbon metabolism.

ABSTRACT:

Background

There are large differences between men and women of child-bearing age in the expression level of 5 key enzymes in one-carbon metabolism almost certainly caused by the sex hormones. These male-female differences in one-carbon metabolism are greatly accentuated during pregnancy. Thus, understanding the origin and consequences of sex differences in one-carbon metabolism is important for precision medicine.

Results

We have created a mathematical model of hepatic one-carbon metabolism based on the underlying physiology and biochemistry. We use the model to investigate the consequences of sex differences in gene expression. We give a mechanistic understanding of observed concentration differences in one-carbon metabolism and explain why women have lower S-andenosylmeth

SUBMITTER: Sadre-Marandi F 

PROVIDER: S-EPMC6201565 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature