Systems-Mapping of Herbal Effects on Complex Diseases Using the Network-Perturbation Signatures.

ABSTRACT: The herbs have proven to hold great potential to improve people's health and wellness during clinical practice over the past millennia. However, herbal medicine for the personalized treatment of disease is still under investigation owing to the complex multi-component interactions in herbs. To reveal the valuable insights for herbal synergistic therapy, we have chosen Traditional Chinese Medicine (TCM) as a case to illustrate the art and science behind the complicated multi-molecular, multi-genes interaction systems, and how the good practices of herbal combination therapy are applicable to personalized treatment. Here, we design system-wide interaction map strategy to provide a generic solution to establish the links between diseases and herbs based on comprehensive testing of molecular s

SUBMITTER: Chen X 

PROVIDER: S-EPMC6201628 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature