Stability enhancement of clinical grade multipotent mesenchymal stromal cell-based products.

ABSTRACT:

Background

Successful delivery of cell-based therapeutics into patients is compromised by their short shelf-life upon release from production facilities due to the living nature of the active component that rapidly loses viability, and therefore its properties. In this context, the use of appropriate additives may contribute to the stabilisation of the cellular component within specifications for a longer time until administration.

Results

In the present study, we evaluated the effect of different formulations on the stability of viability, identity, and potency of clinical grade multipotent mesenchymal stromal cells in suspension, both electrolyte solution and protein content were found to impact on their shelf-life. Particularly cryopreservation of cells in a Plasmalyte 14

SUBMITTER: Mirabel C 

PROVIDER: S-EPMC6201632 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature