Distinct esophageal adenocarcinoma molecular subtype has subtype-specific gene expression and mutation patterns.

ABSTRACT:

Background

Esophageal carcinoma (EC), consists of two histological types, esophageal squamous carcinoma (ESCC) and esophageal adenocarcinoma (EAC). EAC accounted for 10% of EC for centuries; however, the prevalence of EAC has alarmingly risen 6 times and increased to about 50% of EC in recent 30 years in the western countries, while treatment options for EAC patients are still limited. Stratification of molecular subtypes by gene expression profiling methods had offered opportunities for targeted therapies. However, the molecular subtype in EAC has not been defined. Hence, Identification of EAC molecular subtypes is needed and will provide important insights for future new therapies.

Results

We performed meta-analysis of gene expression profiling data on three independent EA

SUBMITTER: Guo X 

PROVIDER: S-EPMC6201634 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature