Serum glycosylation characterization of osteonecrosis of the femoral head by mass spectrometry.

ABSTRACT: Osteonecrosis of the femoral head is a recalcitrant and paralyzing disease often discovered in the end stage at the time of diagnosis, which is often performed by physical examination and diagnostic imaging. Osteonecrosis of the femoral head is typically caused by trauma or long-term steroid use. There are over 30 million patients in the US taking steroids, and roughly 40% will develop osteonecrosis of the femoral head. However, the exact pathophysiological process is not well understood. This study aims to examine the alteration in serum glycosylation of osteonecrosis of the femoral head using the state-of-the-art analytical tools to provide more chemical data for pathophysiology research and possibly biomarker discovery. A training set containing 27 serum samples from steroid-induced ost

SUBMITTER: Song T 

PROVIDER: S-EPMC6201689 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature