A synthetic model of the nonheme iron-superoxo intermediate of cysteine dioxygenase.

ABSTRACT: A nonheme Fe(ii) complex (1) that models substrate-bound cysteine dioxygenase (CDO) reacts with O₂ at -80 °C to yield a purple intermediate (2). Analysis with spectroscopic and computational methods determined that 2 features a thiolate-ligated Fe(iii) center bound to a superoxide radical, mimicking the putative structure of a key CDO intermediate.

SUBMITTER: Fischer AA 

PROVIDER: S-EPMC6201693 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature