Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions.

ABSTRACT: All presently known geroprotective chemical compounds of plant and microbial origin are caloric restriction mimetics because they can mimic the beneficial lifespan- and healthspan-extending effects of caloric restriction diets without the need to limit calorie supply. We have discovered a geroprotective chemical compound of mammalian origin, a bile acid called lithocholic acid, which can delay chronological aging of the budding yeast Saccharomyces cerevisiae under caloric restriction conditions. Here, we investigated mechanisms through which lithocholic acid can delay chronological aging of yeast limited in calorie supply. We provide evidence that lithocholic acid causes a stepwise development and maintenance of an aging-delaying cellular pattern throughout the entire chronological

SUBMITTER: Arlia-Ciommo A 

PROVIDER: S-EPMC6201858 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature