Microbiota stability in healthy individuals after single-dose lactulose challenge-A randomized controlled study.

ABSTRACT:

Background and aims

Lactulose is a common food ingredient and widely used as a treatment for constipation or hepatic encephalopathy and a substrate for hydrogen breath tests. Lactulose is fermented by the colon microbiota resulting in the production of hydrogen (H2). H2 is a substrate for enteropathogens including Salmonella Typhimurium (S. Typhimurium) and increased H2 production upon lactulose ingestion might favor the growth of H2-consuming enteropathogens. We aimed to analyze effects of single-dose lactulose ingestion on the growth of intrinsic Escherichia coli (E. coli), which can be efficiently quantified by plating and which share most metabolic requirements with S. Typhimurium.

Methods

32 healthy volunteers (18 females, 14 males) were recruited. Participants were ran

SUBMITTER: Wotzka SY 

PROVIDER: S-EPMC6201941 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature