Bmi1-Progenitor Cell Ablation Impairs the Angiogenic Response to Myocardial Infarction.

ABSTRACT: Objective- Cardiac progenitor cells reside in the heart in adulthood, although their physiological relevance remains unknown. Here, we demonstrate that after myocardial infarction, adult Bmi1⁺ (B lymphoma Mo-MLV insertion region 1 homolog [PCGF4]) cardiac cells are a key progenitor-like population in cardiac neovascularization during ventricular remodeling. Approach and Results- These cells, which have a strong in vivo differentiation bias, are a mixture of endothelial- and mesenchymal-related cells with in vitro spontaneous endothelial cell differentiation capacity. Genetic lineage tracing analysis showed that heart-resident Bmi1⁺ progenitor cells proliferate after acute myocardial infarction and differentiate to generate de novo cardiac vasculature. In a mouse model

SUBMITTER: Herrero D 

PROVIDER: S-EPMC6202133 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature