Imaging the Vascular Bone Marrow Niche During Inflammatory Stress.

ABSTRACT:

Rationale

Inflammatory stress induced by exposure to bacterial lipopolysaccharide causes hematopoietic stem cell expansion in the bone marrow niche, generating a cellular immune response. As an integral component of the hematopoietic stem cell niche, the bone marrow vasculature regulates the production and release of blood leukocytes, which protect the host against infection but also fuel inflammatory diseases.

Objective

We aimed to develop imaging tools to explore vascular changes in the bone marrow niche during acute inflammation.

Methods and results

Using the TLR (Toll-like receptor) ligand lipopolysaccharide as a prototypical danger signal, we applied multiparametric, multimodality and multiscale imaging to characterize how the bone marrow vasculature adapts when

SUBMITTER: Vandoorne K 

PROVIDER: S-EPMC6202141 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature