Admixture mapping and fine-mapping of type 2 diabetes susceptibility loci in African American women.

ABSTRACT: African American women are disproportionately affected by type 2 diabetes. Genetic factors may explain part of the excess risk. More than 100 genetic variants have been associated with risk of type 2 diabetes, but most studies have been conducted in white populations. Two genome-wide association studies (GWAS) in African Americans have identified three novel genetic variants only. We conducted admixture mapping using 2918 ancestral informative markers in 2632 cases of type 2 diabetes, and 2596 controls nested in the ongoing Black Women's Health Study cohort, with the goal of identifying genomic loci with local African ancestry associated with type 2 diabetes. In addition, we performed replication analysis of 71 previously identified index SNPs, and fine-mapped those genetic loci to identif

SUBMITTER: Uribe-Salazar JM 

PROVIDER: S-EPMC6202164 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature