Efficacy of different types of cognitive enhancers for patients with schizophrenia: a meta-analysis.

ABSTRACT: Cognitive impairment is a core feature of schizophrenia, which is predictive for functional outcomes and is, therefore, a treatment target in itself. Yet, literature on efficacy of different pharmaco-therapeutic options is inconsistent. This quantitative review provides an overview of studies that investigated potential cognitive enhancers in schizophrenia. We included pharmacological agents, which target different neurotransmitter systems and evaluated their efficacy on overall cognitive functioning and seven separate cognitive domains. In total, 93 studies with 5630 patients were included. Cognitive enhancers, when combined across all different neurotransmitter systems, which act on a large number of different mechanisms, showed a significant (yet small) positive effect size of 0.10 (k =

SUBMITTER: Sinkeviciute I 

PROVIDER: S-EPMC6202388 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature