Brain structural alterations are distributed following functional, anatomic and genetic connectivity.

ABSTRACT: The pathological brain is characterized by distributed morphological or structural alterations in the grey matter, which tend to follow identifiable network-like patterns. We analysed the patterns formed by these alterations (increased and decreased grey matter values detected with the voxel-based morphometry technique) conducting an extensive transdiagnostic search of voxel-based morphometry studies in a large variety of brain disorders. We devised an innovative method to construct the networks formed by the structurally co-altered brain areas, which can be considered as pathological structural co-alteration patterns, and to compare these patterns with three associated types of connectivity profiles (functional, anatomical, and genetic). Our study provides transdiagnostical evidence that

SUBMITTER: Cauda F 

PROVIDER: S-EPMC6202577 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature