The clinical impact of miRNA34a and P53 gene expression in colon cancer.

ABSTRACT:

Objective

To study the potential role of miRNA34a gene expression and its relationship with P53 gene expression, fate, stage, metastasis and overall survival of colorectal cancer.

Patients and methods

This study was carried out 30 patients with colon adenocarcinoma, 30 patients with benign colon polyp and 30 apparently healthy persons served as controls. All participants were subjected to full history taking, general clinical examination. Complete blood count, liver and kidney function, determination of serum tumor markers were done. Estimation of microRNA 34a and P53 Gene expression by real-time PCR were done.

Results

There was a significant negative relationship between serum tumor markers and micro RNA 34a gene expression in cancer patients. Also, there was a stati

SUBMITTER: Badr EAE 

PROVIDER: S-EPMC6202666 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature