Circulating EZH2-positive T cells are decreased in multiple sclerosis patients.

ABSTRACT:

Background

Recent studies in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (MS), suggest an involvement of the histone methyltransferase enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) in important processes such as cell adhesion and migration.

Methods

Here, we aimed to expand these initial observations by investigating the role of EZH2 in MS. mRNA expression levels for EZH2 were measured by real-time PCR in peripheral blood mononuclear cells (PBMC) from 121 MS patients (62 untreated and 59 receiving treatment) and 24 healthy controls.

Results

EZH2 expression levels were decreased in PBMC from untreated patients compared to that from controls, and treatment significantly upregulated EZH2 expression. Expression of miR

SUBMITTER: Malhotra S 

PROVIDER: S-EPMC6202809 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature