Cu²⁺ selective chelators relieve copper-induced oxidative stress in vivo.

ABSTRACT: Copper ions are essential for biological function yet are severely detrimental when present in excess. At the molecular level, copper ions catalyze the production of hydroxyl radicals that can irreversibly alter essential bio-molecules. Hence, selective copper chelators that can remove excess copper ions and alleviate oxidative stress will help assuage copper-overload diseases. However, most currently available chelators are non-specific leading to multiple undesirable side-effects. The challenge is to build chelators that can bind to copper ions with high affinity but leave the levels of essential metal ions unaltered. Here we report the design and development of redox-state selective Cu ion chelators that have 10⁸ times higher conditional stability constants toward Cu^2+</

SUBMITTER: Rakshit A 

PROVIDER: S-EPMC6202919 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature