Quantification of hyperpolarisation efficiency in SABRE and SABRE-Relay enhanced NMR spectroscopy.

ABSTRACT: para-Hydrogen (p-H₂) induced polarisation (PHIP) is an increasingly popular method for sensitivity enhancement in NMR spectroscopy. Its growing popularity is due in part to the introduction of the signal amplification by reversible exchange (SABRE) method that generates renewable hyperpolarisation in target analytes in seconds. A key benefit of PHIP and SABRE is that p-H₂ can be relatively easily and cheaply produced, with costs increasing with the desired level of p-H₂ purity. In this work, the efficiency of the SABRE polarisation transfer is explored by measuring the level of analyte hyperpolarisation as a function of the level of p-H₂ enrichment. A linear relationship was found between p-H₂ enrichment and analyte ¹H hyper

SUBMITTER: Richardson PM 

PROVIDER: S-EPMC6202922 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature