Anticoagulant Effects of Dabigatran in Paediatric Patients Compared with Adults: Combined Data from Three Paediatric Clinical Trials.

ABSTRACT:

Background

 Physiological age-related changes in the haemostatic and coagulation systems result in differing anticoagulant assay responses to standard anticoagulants. Therefore, we investigated the response of anticoagulant assays to dabigatran etexilate (DE) in children compared with adults.

Objective

 This article assesses the relationship between plasma dabigatran concentration and coagulation assay results across age groups in children and adults.

Patients and methods

 Data from three clinical trials in which children received DE following standard of care for venous thromboembolism were compared with data from adult clinical trials. The effects of dabigatran concentration on diluted thrombin time (dTT), ecarin clotting time (ECT) and activated partial thromboplas

SUBMITTER: Maas H 

PROVIDER: S-EPMC6202931 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature