Supine plasma NE predicts the pressor response to droxidopa in neurogenic orthostatic hypotension.

ABSTRACT:

Objective

To test whether the plasma levels of norepinephrine (NE) in patients with neurogenic orthostatic hypotension (nOH) predict their pressor response to droxidopa.

Methods

This was an observational study, which included patients with nOH. All patients had standardized autonomic function testing including determination of venous plasma catecholamine levels drawn through an indwelling catheter while resting supine. This was followed by a droxidopa titration with 100 mg increments in successive days until relief of symptoms, side effects, or the maximum dose of 600 mg was reached. No response was defined as an increase of <10 mm Hg in systolic blood pressure (BP) after 3-minute standing 1 hour after droxidopa administration. Nonlinear regression models were used to determ

SUBMITTER: Palma JA 

PROVIDER: S-EPMC6202942 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature