Interactions between TLR4 methylation and alcohol consumption on subjective responses to an alcohol infusion.

ABSTRACT:

Aims

Converging evidence has implicated perturbed inflammatory signaling in alcohol use disorders (AUDs), and both animal and human studies suggest that alcohol-induced inflammatory signaling is mediated by Toll-Like Receptor 4 (TLR4). We previously demonstrated that TLR4 is hypermethylated in subjects with AUD compared to control individuals. Examining the relationship between TLR4 methylation and subjective alcohol responses could shed light on the role of TLR4 in promoting AUDs, thereby highlighting its potential as a treatment target.

Short summary

Significant interactions were demonstrated between Toll-like Receptor 4 (TLR4) methylation and human alcohol consumption patterns, such that greater methylation was associated with decreased positive and negative self-reported

SUBMITTER: Karoly HC 

PROVIDER: S-EPMC6203129 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature