GLI3 knockdown decreases stemness, cell proliferation and invasion in oral squamous cell carcinoma.

ABSTRACT: Oral squamous cell carcinoma (OSCC) is an extremely aggressive disease associated with a poor prognosis. Previous studies have established that cancer stem cells (CSCs) actively participate in OSCC development, progression and resistance to conventional treatments. Furthermore, CSCs frequently exhibit a deregulated expression of normal stem cell signalling pathways, thereby acquiring their distinctive abilities, of which self-renewal is an example. In this study, we examined the effects of GLI3 knockdown in OSCC, as well as the differentially expressed genes in CSC-like cells (CSCLCs) expressing high (CD44high) or low (CD44low) levels of CD44. The prognostic value of GLI3 in OSCC was also evaluated. The OSCC cell lines were sorted based on CD44 expression; gene expression was evaluated usi

SUBMITTER: Rodrigues MFSD 

PROVIDER: S-EPMC6203148 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature