Genomic approaches in the search for molecular biomarkers in chronic kidney disease.

ABSTRACT:

Background

Chronic kidney disease (CKD) is recognised as a global public health problem, more prevalent in older persons and associated with multiple co-morbidities. Diabetes mellitus and hypertension are common aetiologies for CKD, but IgA glomerulonephritis, membranous glomerulonephritis, lupus nephritis and autosomal dominant polycystic kidney disease are also common causes of CKD.

Main body

Conventional biomarkers for CKD involving the use of estimated glomerular filtration rate (eGFR) derived from four variables (serum creatinine, age, gender and ethnicity) are recommended by clinical guidelines for the evaluation, classification, and stratification of CKD. However, these clinical biomarkers present some limitations, especially for early stages of CKD, elderly individua

SUBMITTER: Canadas-Garre M 

PROVIDER: S-EPMC6203198 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature