A SNP-based phylogenetic analysis of Corynebacterium diphtheriae in Malaysia.

ABSTRACT:

Objective

There is a lack of study in Corynebacterium diphtheriae isolates in Malaysia. The alarming surge of cases in year 2016 lead us to evaluate the local clinical C. diphtheriae strains in Malaysia. We conducted single nucleotide polymorphism phylogenetic analysis on the core and pan-genome as well as toxin and diphtheria toxin repressor (DtxR) genes of Malaysian C. diphtheriae isolates from the year 1986-2016.

Results

The comparison between core and pan-genomic comparison showed variation in the distribution of C. diphtheriae. The local isolates portrayed a heterogenous trait and a close relationship between Malaysia's and Belarus's, Africa's and India's strains were observed. A toxigenic C. diphtheriae clone was noted to be circulating in the Malaysian population for

SUBMITTER: Hii SYF 

PROVIDER: S-EPMC6203263 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature