Canonical and single-cell Hi-C reveal distinct chromatin interaction sub-networks of mammalian transcription factors.

ABSTRACT:

Background

Transcription factor (TF) binding to regulatory DNA sites is a key determinant of cell identity within multi-cellular organisms and has been studied extensively in relation to site affinity and chromatin modifications. There has been a strong focus on the inference of TF-gene regulatory networks and TF-TF physical interaction networks. Here, we present a third type of TF network, the spatial network of co-localized TF binding sites within the three-dimensional genome.

Results

Using published canonical Hi-C data and single-cell genome structures, we assess the spatial proximity of a genome-wide array of potential TF-TF co-localizations in human and mouse cell lines. For individual TFs, the abundance of occupied binding sites shows a positive correspondence with the

SUBMITTER: Ma X 

PROVIDER: S-EPMC6203279 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature