Cytoreductive Surgery for Metastatic Gastrointestinal Stromal Tumors Treated With Tyrosine Kinase Inhibitors: A 2-institutional Analysis.

ABSTRACT:

Objective

To refine treatment recommendations for patients with metastatic gastrointestinal stromal tumors (GISTs) treated with tyrosine kinase inhibitors (TKIs) and surgery.

Background

Early reports suggested that patients with metastatic GIST responding to TKIs treated with surgery may have favorable outcomes. However, identification of prognostic factors was limited by small cohorts.

Methods

Progression-free survival (PFS) and overall survival (OS) from time of surgery and from start of initial TKI was determined. Multivariate analysis was conducted on all patients undergoing GIST metastasectomy between 2001 and 2014 at 2 institutions.

Results

We performed 400 operations on 323 patients with metastatic GIST on TKIs. Radiographic response at time of surgery w

SUBMITTER: Fairweather M 

PROVIDER: S-EPMC6203295 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature