Aldosterone, Hypertension, and Antihypertensive Therapy: Insights From a General Population.

ABSTRACT:

Objective

To investigate the relationships among aldosterone level, use of antihypertensive (anti-HTN) medications, clinical profile, and atrial natriuretic peptide (ANP) level in individuals with HTN.

Participants and methods

In a community-based cohort, we analyzed aldosterone plasma levels based on the presence (n=477) or absence (n=1073) of HTN. In individuals with HTN, we evaluated circulating aldosterone levels according to the number of anti-HTN drugs used, analyzed the associated clinical characteristics, and determined the relationship to the counterregulatory cardiac hormone ANP. Data were collected from August 25, 1997, through September 5, 2000.

Results

Participants with HTN had higher serum aldosterone levels than those without HTN (6.4 vs 4.1 ng/dL [to c

SUBMITTER: Cannone V 

PROVIDER: S-EPMC6203321 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature