Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression.

ABSTRACT: Myelin transcription factor 1 (Myt1) and Myt1l (Myt1-like) are zinc finger transcription factors that regulate neuronal differentiation. Reduced Myt1l expression has been implicated in glioblastoma (GBM), and the related St18 was originally identified as a potential tumor suppressor for breast cancer. We previously analyzed changes in gene expression in a human GBM cell line with re-expression of either Myt1 or Myt1l. This revealed largely overlapping gene expression changes, suggesting similar function in these cells. Here we show that re-expression of Myt1 or Myt1l reduces proliferation in two different GBM cell lines, activates gene expression programs associated with neuronal differentiation, and limits expression of proliferative and epithelial to mesenchymal transition gene-sets. Con

SUBMITTER: Melhuish TA 

PROVIDER: S-EPMC6203443 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature