Association of MMP-8 rs2012390 and rs11225394 polymorphisms with osteonecrosis of the femoral head risks: Evidence from a meta-analysis.

ABSTRACT:

Background

The association of MMP-8 rs2012390 and rs11225394 polymorphisms with osteonecrosis of the femoral head (ONFH) risks was investigated in several studies with conflicting results. We performed the meta-analysis to evaluate the association between them.

Methods

Potentially relevant literatures were searched from the electronic databases of PubMed, Web of Science, and Cochrane Library. All databases were searched up to May 6, 2018. The strength of associations of the MMP-8 rs2012390 and rs11225394 polymorphisms with ONFH risk was assessed by crude odds ratios (ORs) with their 95% confidence intervals (CIs) under different genetic models.

Results

A total of 1469 cases diagnosed with ONFH and 1211 healthy controls were included in the current meta-analysis. A rem

SUBMITTER: Jiang L 

PROVIDER: S-EPMC6203581 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature