Intentional Weight Loss in Overweight and Obese Patients With Knee Osteoarthritis: Is More Better?

ABSTRACT:

Objective

To determine the dose response effect of weight loss on clinical and mechanistic outcomes in overweight and obese adults with knee osteoarthritis (OA).

Methods

This is a secondary analysis of the diet-induced weight loss only (D) and diet-induced weight loss plus exercise (D + E) groups in the Intensive Diet and Exercise for Arthritis randomized controlled clinical trial. The 240 participants were overweight and obese older community-dwelling adults with pain and radiographic knee OA. Participants were assigned to 1 of 4 groups according to weight loss achieved over an 18-month period: <5% (<5% group), 5-10% (≥5% group), 10-20% (≥10% group), and >20% (≥20% group).

Results

There were significant dose responses to weight loss for pain (P = 0.01), function (P =

SUBMITTER: Messier SP 

PROVIDER: S-EPMC6203601 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature