Acute HIV Infection and CD4/CD8 Ratio Normalization After Antiretroviral Therapy Initiation.

ABSTRACT:

Background

We estimated the effect of initiating virologically suppressive antiretroviral therapy (ART) during acute HIV infection versus chronic HIV infection (AHI vs. CHI) on CD4/CD8 ratio normalization.

Setting

A prospective clinical cohort study.

Methods

We included patients initiating ART with AHI and CHI between 2000 and 2015 and compared time from ART initiation to the first normal CD4/CD8 ratio (defined as CD4/CD8 ≥1) using Kaplan-Meier curves and multivariable Cox proportional hazards models. Patient time was censored at virologic failure, lost to follow-up, or death. We also characterized CD4, CD8, and CD4/CD8 trajectories over the first 3 years of ART.

Results

The 1198 patients were 27% female and 60% African American, with a median age of 37 years (

SUBMITTER: Davy-Mendez T 

PROVIDER: S-EPMC6203616 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature