Factors Associated With Progression of Lung Function Abnormalities in HIV-Infected Individuals.

ABSTRACT: BACKGROUND:HIV is an independent risk factor for chronic obstructive pulmonary disease; however, baseline risk factors for lung function decline remain largely unknown in this population. METHODS:HIV-infected participants in the Pittsburgh Lung HIV Cohort with at least 3 pulmonary function measurements between 2007 and 2016 were included. Pulmonary function testing including postbronchodilator (BD) spirometry and diffusion capacity for carbon monoxide (DLco) was performed every 18 months. We used a mixed-effect linear model to evaluate factors associated with pulmonary function testing and DLco decline and logistic regression models to evaluate factors associated with rapid FEV1 decline (defined as >80 mL per year) and any DLco decline. RESULTS:Two hundred eighty-five HIV-infected particip

SUBMITTER: Li Y 

PROVIDER: S-EPMC6203646 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature