D-dimer and high-sensitivity C-reactive protein levels to predict venous thromboembolism recurrence after discontinuation of anticoagulation for cancer-associated thrombosis.

ABSTRACT:

Background

Optimal duration of anticoagulation for cancer-associated thrombosis (CAT) remains unclear. This study assessed D-dimer (DD) and high-sensitivity C-reactive protein (hs-CRP) levels after the withdrawal of anticoagulation treatment to predict the risk of venous thromboembolism (VTE) recurrence among patients with CAT.

Methods

Prospective, multicentre study to evaluate CAT with ≥3 months of anticoagulation that was subsequently discontinued. Blood samples were taken when patients stopped the anticoagulation and 21 days later to determine the DD and hs-CRP levels. All patients were followed up for 6 months to detect VTE recurrence.

Results

Between 2013 and 2015, 325 patients were evaluated and 114 patients were ultimately enrolled in the study. The mean age wa

SUBMITTER: Jara-Palomares L 

PROVIDER: S-EPMC6203717 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature