Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status.

ABSTRACT: Although thimerosal, an ethylmercury-based preservative, has been removed from most pediatric vaccines in the United States, some multidose vaccines, such as influenza vaccines, still contain thimerosal. Considering that a growing number of studies indicate involvement of the gut microbiome in infant immune development and vaccine responses, it is important to elucidate the impact of pediatric vaccines, including thimerosal-containing vaccines, on gut microbial structure and function. Here, a non-human primate model was utilized to assess how two vaccine schedules affect the gut microbiome in infants (5-9 days old) and juveniles (77-88 weeks old) through 16S ribosomal RNA sequencing and metabolomics analyses of the fecal samples. Two treatment groups (n = 12/group) followed either the vacc

SUBMITTER: Hasegawa Y 

PROVIDER: S-EPMC6203732 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature