Efficient control of chronic LCMV infection by a CD4 T cell epitope-based heterologous prime-boost vaccination in a murine model.

ABSTRACT: CD4⁺ T cells are essential for sustaining CD8⁺ T cell responses during a chronic infection. The adoptive transfer of virus-specific CD4⁺ T cells has been shown to efficiently rescue exhausted CD8⁺ T cells. However, the question of whether endogenous virus-specific CD4⁺ T cell responses can be enhanced by certain vaccination strategies and subsequently reinvigorate exhausted CD8⁺ T cells remains unexplored. In this study, we developed a CD4⁺ T cell epitope-based heterologous prime-boost immunization strategy and examined the efficacy of this strategy using a mouse model of chronic lymphocytic choriomeningitis virus (LCMV) infection. We primed chronically LCMV-infected mice with a Listeria monocytogenes vector that

SUBMITTER: He R 

PROVIDER: S-EPMC6203753 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature