Ontology highlight
ABSTRACT:
SUBMITTER: Wei Z
PROVIDER: S-EPMC6203763 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Nature communications 20181026 1
The conversion of serine and glycine that is accomplished by serine hydroxymethyltransferase 2 (SHMT2) in mitochondria is significantly upregulated in various cancers to support cancer cell proliferation. In this study, we observed that SHMT2 is acetylated at K95 in colorectal cancer (CRC) cells. SIRT3, the major deacetylase in mitochondria, is responsible for SHMT2 deacetylation. SHMT2-K95-Ac disrupts its functional tetramer structure and inhibits its enzymatic activity. SHMT2-K95-Ac also promo ...[more]